What is L-Citrulline DL-Malate?
L-citrulline is an amino acid found naturally in foods like watermelon, squash, melons, cucumber, and pumpkin. L-citrulline is produced in the liver and intestines and plays an important role in muscle strength, heart health, the production of important enzymes, and increasing arginine levels.
L-citrulline DL-malate is citrulline with an added malic acid component. Malate, or malic acid, is a naturally occurring organic compound found in a variety of fruit.
When combined with citrulline, malic acid has been shown to promote better absorption and higher bioavailability. However, some studies also suggest that malic acid may have some potential benefits of its own, including supporting pain management and increased physical energy.
Several studies [1,2,3,4] indicate that L-citrulline reduces fatigue during and after exercise, and increased work capacity in both aerobic and anaerobic exercise. Participants also reported less soreness after exercise.
A single-blind study of 24 men over the age of 55 showed that L-citrulline improves erectile dysfunction (ED) and increases the hardness of erections. Some men reported having more sex after treatment and being more satisfied .
A study of 10 healthy young men found that nitric oxide plays an important role in regulating blood flow . Other studies, one being a DB-RCT, found that L-citrulline effectively increases nitric oxide [1, 2]. This suggests that L-citrulline may increase blood flow.
A study of 30 patients with heart failure found that l-citrulline increased the volume of blood pumped out of the right ventricle of the heart and lowered blood pressure in the pulmonary artery [1, 2]. This suggests that overall heart function may be improved.
A study (DB-RCT) on 17 male cyclists found that L-citrulline supplementation before exercise may boost immunity. Neutrophils (a type of white blood cell) of the cyclists supplemented with L-citrulline showed improved ability to fight infection .
How it Works
After ingestion, L-citrulline is converted to L-arginine by the kidneys and is released into the bloodstream by the kidneys so that it is available to the whole body.
L-arginine, a precursor to nitric oxide. Nitric oxide synthase produces nitric oxide from L-arginine. Nitric oxide plays a crucial role in the immune system and heart and blood vessel health. Many of the benefits of L-citrulline are due to L-arginine and nitric oxide.
As a dietary supplement, take 3000mg (rounded tsp) twice a day, or as directed by a physician. The recommended dose
of L-Citrulline DL-Malate is 3 to 4 grams twice per day. The first dose is best taken in the morning, and the second may be taken 45 min before physical activity.
Caution: If you are pregnant, nursing, taking any medications or have any medical condition consult your physician before use. Keep out of reach of children.